| Year | Event | Category | Film | Result |
|---|---|---|---|---|
| 2024 | Venice Film Festival | Volpi Cup - Best Actress | Babygirl | Winner |
| 2022 | Academy Awards | Best Actress | (2021) | Nominated |
| 2021 | Golden Globe Awards | Best Actress - Drama | (2021) | Winner |
| 2017 | Academy Awards | Best Supporting Actress | (2016) | Nominated |
| 2011 | Academy Awards | Best Actress | Rabbit Hole | Nominated |
| 2003 | Academy Awards | Best Actress | (2002) | Winner |
| 2003 | Berlin International Film Festival | Silver Bear - Best Leading Performance | (2002) | Winner |
| 2002 | British Academy Film Awards | Best Leading Actress | (2002) | Winner |
| 2002 | Golden Globe Awards | Best Actress - Drama | (2002) | Winner |
| 2002 | Academy Awards | Best Actress | (2001) | Nominated |